S-BPM ONE 2020, the 12th International Conference on Subject-Oriented Business Process Management, originally planned to be held at BIBA in Bremen in July, has now taken place as an online conference on December 2-3, 2020. Its theme was "The Digital Workplace - Nucleus of Transformation" and a good part of the presentations addressed modeling, analysis and management of business processes in cyber-physical and Industry 4.0 processes. More information can be found at s-bpm-one.org. Herbert Kindermann's keynote address and the 15 accepted papers of the conference are documented in the conference proceedings, which are published in the Springer series Communications in Computer and Information Science (CCIS) as Volume 1278 (see www.springer.com/gp/book/9783030643508).